DOSAGE: Yet One More in the Endless List of Studies Showing Higher Methadone Maintenance Dosage Improves Outcome
Journal Addiction, vol. 100, 2005 (pp 1496-1509)
It is reported that "larger methadone doses . . .completely blocked the subjective effects of heroin... " The results are summarized as follows: "the results of this study show that larger doses of methadone are more effective in reducing heroin self-administration and suggest that the mechanism of this increased efficacy is by reduction of the positively reinforcing/euphoric effects of heroin (i.e., cross tolerance)." So what else is new…?